Sonobiopsies generate genetic, molecular data to inform treatment decisions for brain diseases
Noninvasive, ultrasound-based brain biopsy is feasible, safe in people
Category: Neurovascular Injury & Repair
New Technique for Diagnosing Brain Diseases is Successfully Put to the Test
Hong Chen, PhD, associate professor of biomedical engineering and radiation oncology at Washington University in St. Louis, is dedicated to what may seem like the impossible. “This constant puzzle of what’s happening in my brain.” Chen is referring to all human brains that share this complexity. And getting answers to serious problems can be very […]
NIH funds study of ultrasound with genetics to treat brain disorders
Researchers have developed methods to study and manipulate areas of the brain, though many of those methods are restricted by the limited depth that light can reach within the brain. A multidisciplinary team at Washington University in St. Louis plans to overcome that limitation by integrating ultrasound with genetics to precisely modify neurons in the […]
Induction of a torpor-like state with ultrasound
Some mammals and birds have a clever way to preserve energy and heat by going into torpor, during which their body temperature and metabolic rate drop to allow them to survive potentially fatal conditions in the environment, such as extreme cold or lack of food. While a similar condition was proposed for scientists making flights […]
Insight into brain’s waste clearing system may shed light on brain diseases
Like the lymphatic system in the body, the glymphatic system in the brain clears metabolic waste and distributes nutrients and other important compounds. Impairments in this system may contribute to brain diseases, such as neurodegenerative diseases and stroke. A team of researchers in the McKelvey School of Engineering at Washington University in St. Louis has […]
Mind-body connection is built into brain, study suggests
Findings point to brain areas that integrate planning, purpose, physiology, behavior, movement
Disrupted flow of brain fluid may underlie neurodevelopmental disorders
New imaging technique reveals circulation patterns in developing brain
Focused ultrasound technique leads to release of neurodegenerative disorders biomarkers
Research could facilitate diagnosis of Alzheimer’s disease
Rejuvenated immune cells can improve clearance of toxic waste from brain
Findings in mice suggest new therapeutic approach to Alzheimer’s, other age-related diseases
Understanding, treating pain, reducing opioid use, aim of $11.7 million grant
Funding from NIH HEAL Initiative
Multi-scale imaging technique may enable objective assessment of myofascial pain
Song Hu, Yong Wang team up to find quantitative biomarkers for clinical pain management
A sound approach for effective gene therapy delivery to brain
Hong Chen’s lab develops noninvasive focused ultrasound intranasal delivery method
High-tech imaging focuses on oxygen metabolism in newborn brain
Our brains consume huge amounts of energy and rely on oxygen supplied by blood vessels. When the brains of infants are deprived of oxygen for any reason, it can lead to brain injury that causes cerebral palsy, epilepsy or cognitive impairment. Song Hu, PhD, associate professor of biomedical engineering in the McKelvey School of Engineering […]
New practical method of producing Airy beams could enhance ultrasound
Hong Chen’s lab develops technique to generate Airy beams for ultrasound focusing
A one-two punch for photoacoustic imaging
Song Hu combines hardware and machine learning for precision imaging technique
Wearable ultrasound sensors for human brain in development
A submarine can inadvertently reveal its location because of cavitation, a condition that creates bubbles underwater that burst, then emit sound waves that can be detected by sonar. A team of biomedical engineers at Washington University in St. Louis plans to use the same concept to detect cavitation in human brains that may contribute to […]
Calming overexcited neurons may protect brain after stroke
New data prompts reconsideration of decades-old theory about brain injury due to stroke
For accuracy, brain studies of complex behavior require thousands of people
Findings will encourage more data sharing, collaboration among researchers
Low-cost, 3D printed device may broaden use of focused ultrasound technique
Hong Chen’s lab created an $80 device that is accurate and easy to use
Less energy, better quality PAM images with machine learning
The two-step denoising technique was developed in Song Hu’s lab
Noninvasive brain biopsy shows improved sensitivity in tumor detection
Hong Chen and Eric Leuthardt’s sonobiopsy method uses blood test instead of surgery
Board grants faculty appointments, promotions, tenure
At the Washington University in St. Louis Board of Trustees meeting Oct. 1, numerous faculty members were appointed or promoted with tenure or granted tenure, effective that day. Promotion with tenure Su-Hsin Chang, PhD, to associate professor of surgery (public health services) at the School of Medicine; Milan G. Chheda, MD, to associate professor of medicine […]
Cho receives NIH grants
Three-year and two-year grants totaling $2.4M
‘First-in-class’ tool for potential treatment of brain disorders
Hong Chen, medical school faculty to collaborate on NIH-funded work
‘Unprecedented opportunity’ to understand neurovascular recovery after stroke
Song Hu, Lan Yang, Jin-Moo Lee, MD, PhD collaborate on NIH-funded work
Memory disorders after viral infections focus of $8.7 million grant
Research program investigates link between viral infections, memory problems
MRI’s magnetic field affects focused ultrasound technology
Finding prompts researchers, clinicians to consider impact in future research, clinical treatment of brain diseases
Lee named head of Department of Neurology
Recognized for expertise in brain injury, impact as mentor
Board grants faculty appointments, promotions, tenure
At the Washington University in St. Louis Board of Trustees meeting May 7, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Megan Tierney Baldridge, MD, PhD, to associate professor of medicine at the School of Medicine; Trevor G. Gardner II to professor of […]
Studies reveal skull as unexpected source of brain immunity
Immune cells from skull bone marrow guard the brain, spinal cord
New tool activates deep brain neurons by combining ultrasound, genetics
It is the first work to show that sonothermogenetics can control behavior by stimulating a specific target deep in the brain
Draining brain’s debris enhances Alzheimer’s therapies in mice
Impaired drainage also may play a role in Alzheimer’s in people
FUSIN promising in therapeutic agent delivery to brain tumor
Dezhuang Ye in Hong Chen’s lab tests novel method in brain tumor model