Archives of BIO 5663: Neurobiology of Disease course
January 16, 2018
Chris Weihl, MD, PhD: Course Introduction
January 23, 2018
Erik Musiek, MD, PhD: Alzheimer’s Disease
- Clinical and biomarker changes in dominantly inherited Alzheimer’s disease
- TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
Review: Three dimensions of the amyloid hypothesis: time, space and ‘wingmen’
January 30, 2018
Deanna Barch, PhD: Psychiatric disorders
- Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study
- Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
Review: The nature of dopamine dysfunction in schizophrenia and what this means for treatment
February 6, 2018
Toni Pearson, MD: Child metabolic
- Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein
- GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak
Review:
- Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay (initial description)
- Phenotypic spectrum of glucose transporter type 1 deficiency syndrome (Glut1 DS)
February 13, 2018
Stefanie Geisler, MD, PhD: Neuropathy
- Gut microbiota is critical for the induction of chemotherapy-induced pain
- Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy
Review: Chemotherapy-induced peripheral neuropathy: A current review
February 20, 2018
Mike Wong, MD, PhD: Epilepsy
- Somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia
- Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy
Review: Molecular mechanisms of epilepsy
February 27, 2018
Milan Chheda, MD, PhD: Neuro-oncology
- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
- Identification of a cancer stem cell in human brain tumors
Review: Identification of human brain tumour initiating cells
March 6, 2018
O’Leary Prize
March 13, 2018
Spring Break
March 20, 2018
Tim Miller, MD, PhD: ALS
- TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics
- Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
March 27, 2018
Alex Carter, MD, PhD: Neuro-Rehabilitation
- Frontal lesions predict response to prism adaptation treatment in spatial neglect – a randomized controlled study
- Theta burst stimulation reduces disability during the activities of daily living in spatial neglect
April 3, 2018
Yo-El Ju, MD: Sleep
- Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility-weighted imaging in idiopathic rapid eye movement sleep behavior disorder
- Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study
Review: Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
April 10, 2018
Hope Center Retreat
April 17, 2018
Chris Weihl, MD, PhD: Myositis
- Targeting protein homeostasis in sporadic inclusion body myositis
- Inclusion body myositis functional rating scale: a reliable and valid measure of disease severity
- A prospective natural history study of inclusion body myositis: implications for clinical trials
April 24, 2018
Pietro Mazzoni, MD, PhD: Movement disorders
January 19, 2016
Chris Weihl, MD, PhD: Course Introduction
January 26, 2016
David Brody, MD, PhD: Traumatic Brain Injury
Student Presenters: Andrew Badachhape, Nicholas White
- Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration
- Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury
February 2, 2016
Beau Ances, MD, PhD, MSc: HIV dementia or AD dementia
Student Presenters: Deep Hathi, Jennifer Pardieck
- Does Older Age Confer an Increased Risk of Incident Neurocognitive Disorders Among Persons Living with HIV Disease?
- Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection.
Review: HIV-associated neurocognitive disorder
February 9, 2016
Gregory Wu, MD, PhD: Multiple Sclerosis
Student Presenters: Peter Myers, Jie Wen
- Structural and functional features of central nervous system lymphatic vessels.
- Natalizumab plus interferon beta-1a for relapsing multiple sclerosis.
February 16, 2016
Yo-El Ju, MD: Sleep Medicine
Student Presenters: Richard Pham, Peter Wang
- Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study
- Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study.
Review: Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Disease.
February 23, 2016
Joan Luby, MD: Early emotional development
Student Presenters: Kael White, Maria Doulatova
- The effects of poverty on childhood brain development: the mediating effect of caregiving and stressful life events.
- Early Childhood Depression and Alterations in the Trajectory of Gray Matter Maturation in Middle Childhood and Early Adolescence.
March 1, 2016
O’Leary Prize
March 8, 2016
Chris Smyser, MD: Neonatal neurology
Student Presenters: Elinor Harrison, Erin Reinl
- “Concurrent Erythropoietin and Hypothermia Treatment Improve Outcomes in a Term Nonhuman Primate Model of Perinatal Asphyxia”
- “Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy”
Review:
- Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy.
- Childhood outcomes after hypothermia for neonatal encephalopathy.
March 15, 2016
Spring Break
March 22, 2016
Alexandre Carter, MD, PhD: Neurorehab
Student Presenters: Kimberly Waddell, Andy Daniel
- Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins
- Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy
March 29, 2016
Susan Culican, MD, PhD: Retinal degeneration
Student Presenters: Jiyao Zhu, Alex Cammack
- Randomized trial of treatment of amblyopia in children aged 7 to 17 years
- Refinement of the retinogeniculate synapse by bouton clustering
Review
April 5, 2016
Scott Norris, MD: Parkinson’s Disease
Student Presenters: Helen Li, Keith Dyson
- Cerebellothalamocortical connectivity regulates penetrance in dystonia
- MPTP induces dystonia and parkinsonism. Clues to the pathophysiology of dystonia
Review
April 12, 2016
Erik Musiek, MD, PhD: Alzheimer’s Disease
Student Presenters: Brian Lananna, Nikki Maughan
- Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models
- Clinical and biomarker changes in dominantly inherited Alzheimer’s disease
April 19, 2016
Susan Searles-Nielsen, PhD: Neuro-Epidemiology
Student Presenter: Katherine Conen
- Traumatic brain injury in later life increases risk for Parkinson disease
- Air pollution from traffic and risk for brain tumors: a nationwide study in Denmark
April 26, 2016
Tim Miller, MD, PhD: ALS
Student Presenters: Jane Hettinger, Matheus Victor
January 14, 2014
Course Introduction
- Weihl Presentation
- “Believe it or not: how much can we rely on published data on potential drug targets”
- “Drug development: Raise standards for preclinical cancer research”
- TA Presentation
- PLD3 Presentation
January 21, 2014
Marc Diamond, MD: Tau propagation
Student Presenters: Joey Benetatos, Geo Taylor
- “Neurodegenerative diseases target large-scale human brain networks “
- “Propagation of tau pathology in a model of early Alzheimer’s disease“
- Review: “Cellular mechanisms of protein aggregate propagation“
January 28, 2014
David Holtzman, MD: Alzheimer Disease
Student Presenters: Sarah Kaufman, Matt Brier
- “Sleep Drives Metabolite Clearance from the Adult Brain”
- “Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls”
- Review, “Alzheimer’s disease: the challenge of the second century”
February 4, 2014
Joan Luby, MD: Early Emotional Development
Student Presenters: Christina Mazuski, Tahnbee Kim
- “Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception”
- “Intellectual ability and cortical development in children and adolescents”
- Review: “The Importance of Early Experience for Neuro-Affective Development”
February 11, 2014
Eric Leuthardt, MD: Neuroprosthetics
Student Presenters: Hanlin Wan, Jordan McCall
- “A brain-computer interface using electrocorticographic signals in humans”
- “Unique cortical physiology associated with ipsilateral hand movements and neuroprosthetic implications”
- Review: “Brain-Computer Interfaces Using Electrocorticographic Signals”
February 18, 2014
Matthew Harms, MD: Genetics of neuromuscular disease
Student Presenters: Mariah Lawler, Amy Clippinger
- “The FSHD2 gene SMCHD1 is a modifier of disease severity in families affected by FSHD1“
- “Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2”
February 25, 2014
Daniel Ory, MD: Niemann-Pick C
Student Presenters: Michal Skowyra, Yang Shi
- “NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes”
- “Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse”
March 4, 2014
David Brody, MD, PhD: Traumatic Brain Injury
Student Presenters: Xinyu Song, Ericka Merriwether
- “Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration”
- “Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury”
March 11, 2014
University Spring Break
March 18, 2014
Yo-El Ju, MD: Sleep Medicine
Student Presenters: Tenira Townsend, Elizabeth Clipperton
- “Abnormal metabolic network activity in REM sleep behavior disorder”
- “Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder”
- Review: “The neuronal network responsible for paradoxical sleep and its dysfunction causing narcolepsy and rapid eye movement (REM) behavior disorder”
- Review: “REM Sleep Behavior Disorder: Clinical, Developmental, and Neuroscience Perspectives 16 Years After Its Formal Identification in SLEEP”
March 25, 2014
Timothy Miller, MD, PhD: Amyotrophic Lateral Sclerosis
Student Presenters: Alex Holehouse, Wade Self
- “The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.“
- “Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration”
April 1, 2014
Albert Kim, MD, PhD: Neuro-oncology
Student Presenters: Chaoyi Kang, Alex Lu
- “Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma”
- “A restricted cell population propagates glioblastoma growth after chemotherapy”
- Background: “Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1”
April 8, 2014
Chris Smyser, MD: Neonatal Neurology
Student Presenters: Jaime Vaquer, Anna Boone
- “Concurrent Erythropoietin and Hypothermia Treatment Improve Outcomes in a Term Nonhuman Primate Model of Perinatal Asphyxia”
- “Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy”
- Review: “Treatment advances in neonatal neuroprotection and neurointensive care”
- Review: “Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs”
April 15, 2014
No Class–Hope Center Retreat
April 22, 2014
John Pruett, MD, PhD: Autism
Student Presenters: Naveen Reddy, Krissy Sakers
- “Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism”
- “The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism”
- Review: “Autism and pervasive developmental disorders”
- Review: “Developmental pathways to autism: A review of prospective studies of infants at risk “
April 29, 2014
Robyn Klein, MD, PhD: Neurovirology
Student Presenters: Apurwa Sharma, Youjin Lee
January 17, 2012
Course Introduction
January 24, 2012
David Brody, MD, PhD: TBI
Student Presenters: Brian Daniels, Lauren Walker
Secondary Readers: Josiah Gerdts, Matt Vail
- Gennarelli TA, et. al., Diffuse axonal injury and traumatic coma in the primate. Ann Neurol. 1982 Dec;12(6):564-74.
- Tang-Schomer MD, et. al., Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration. FASEB J. 2010 May;24(5):1401-10.
- REVIEW: Smith DH, et. al., Diffuse axonal injury in head trauma. J Head Trauma Rehabil. 2003 Jul-Aug;18(4):307-16.
January 31, 2012
Marc Diamond, MD: Tau/prions
Student Presenters: Nisha Iyer, Ashleigh Castner
Secondary Readers: Hao Xu, Charles Shyng
- Munch C, et. al., Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. PNAS. 2011 Mar 1;108(9):3548-53.
- Clavaquera F, et. al., Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009 Jul;11(7):909-13.
- REVIEW: Frost B and Diamond MI, Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci. 2010 Mar;11(3):155-9.
February 7, 2012
Tim Miller, MD, PhD: ALS
Student Presenters: Sarah Wahlstrom Helgren, Mohit Harsh
Secondary Readers: Shivam Shah, Kaitlin Burlingame
- DeJesus-Hernandez M, et. al., Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 2011 Oct 20;72(2):245-56.
- Renton AE, et. al., A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 2011 Oct 20;72(2):257-68.
- Deng HX, et. al., Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature. 2011 Aug 21;477(7363):211-5.
- REVIEW: Rothstein JD. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol. 2009 Jan;65.
February 14, 2012
Beau Ances, MD, PhD: HIV Dementia
Student Presenters: Hao Xu, Shivam Shah
Secondary Readers: Ashleigh Castner, Mohit Harsh
- Ances BM, et. al., HIV infection and aging independently affect brain function as measured by functional magnetic resonance imaging. J Infect Dis. 2010 Feb 1;201(3):336-40.
- Letendre S, et. al., Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol. 2008 Jan;65(1):65-70.
- REFERENCE: Antinori A, et. al., Updated research nosology for HIV-associated neurocognitive disorders. Neurology. 2007 Oct 30;69(18):1789-99.
- REVIEW: Heaton RK, et. al., HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology. 2010 Dec 7;75(23):2087-96.
- REVIEW: McArthur JC, et. al., Human immunodeficiency virus-associated neurocognitive disorders: Mind the gap. Ann Neurol. 2010 Jun;67(6):699-714.
- REVIEW: Gannon P, et. al., Current understanding of HIV-associated neurocognitive disorders pathogenesis. Curr Opin Neurol. 2011 Jun;24(3):275-83.
February 21, 2012
Chris Gurnett, MD, PhD: Genetics of Epilepsy
Student Presenters: Ganesh Babulal, Matt Vail
Secondary Readers: Dan O’Brien, Sarah DeVos
- Berkovic SF, et. al., De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: a retrospective study. Lancet Neurol. 2006 Jun;5(6):488-92.
- Schuchmann S, et. al., Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. Nat Med. 2006 Jul;12(7):817-23.
February 28, 2012
Brad Schlaggar, MD, PhD: Tourettes
Student Presenters: Lenny Ramsey, Kaitlin Burlingame
Secondary Readers: Erica Koval, Laura Marquardt
- McCairn KW, et. al., The neurophysiological correlates of motor tics following focal striatal disinhibition. Brain 2009 132(8):2125-2138.
- Sowell ER, et. al., Thinning of sensorimotor cortices in children with Tourette syndrome. Nat Neurosci. 2008 Jun;11(6):637-9.
- REVIEW: Ablin RL & Mink JW. Recent advances in Tourette syndrome research. Trends Neurosci. 2006 Mar;29(3):175-82.
March 6, 2012
Mike Wong, MD, PhD: Epilepsy
Student Presenters: Christine Wroge, Mrinal Pahwa
Secondary Readers: Sarah Wahlstrom Helgren, Thomas Wilems
- Dzhala VI, et. al., NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005 Nov;11(11):1205-13.
- Goto J, et. al., Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. PNAS. 2011 Nov 8;108(45):E1070-9.
March 12, 2012
University Spring Break
March 20, 2012
Chris Weihl, MD, PhD: Protein aggregate mypoathies
Student Presenters: Lin Bai, Mohammad Maktabi
Secondary Readers: Lenny Ramsey, Brian Daniels
- Sarparanta, J., P. H. Jonson, et al. (2012). “Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.” Nat Genet advance online publication.
- Schessl J, et. al., Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy. J Clin Invest. 2008 Mar;118(3):904-12.
March 27, 2012
Paul Kotzbauer, MD, PhD: Parkinson’s Disease
Student Presenters: Haoxin Sun, Erica Koval
Secondary Readers: Nisha Iyer, Mrinal Pahwa
- Compta Y, et. al., Lewy- and Alzheimer-type pathologies in Parkinson’s disease dementia: which is more important? Brain. 2011 May;134(Pt 5):1493-505.
- Conway KA, et. al., Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson’s disease: implications for pathogenesis and therapy. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):571-6.
April 3, 2012
Jin-Moo Lee, MD, PhD: Stroke
Student Presenters: Brandon Holmes, Ameair Irqeba
Secondary Readers: Haoxin Sun, Ganesh Babulal
- Herzig MC, et. al., Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004 Sep;7(9):954-60. Epub 2004 Aug 15.
- McGowan E, et. al., Aβ42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 2005 Jul 21;47(2):191-9.
April 10, 2012
No class – Symposium on Translational Neuroscience
April 17, 2012
Robyn Klein, MD, PhD: Neuroimmunology
Student Presenters: Charles Shyng, Laura Marquardt
Secondary Readers: Christine Wroge, Brandon Holmes
- Brien JD, et. al., Key role of T cell defects in age-related vulnerability to West Nile virus. J Exp Med. 2009 Nov 23;206(12):2735-45. Epub 2009 Nov 9.
- Hooper DC, et. al., The Production of Antibody by Invading B Cells Is Required for the Clearance of Rabies Virus from the Central Nervous System. PLoS Negl Trop Dis. 2009 Oct 6;3(10):e535.
- Review: Lim SM, et. al., West Nile Virus: Immunity and Pathogenesis. Viruses. 2011 Jun;3(6):811-28. Epub 2011 Jun 15.
April 24, 2012
Michael Crowder, MD, PhD: Post-operative cognitive changes/hypoxia
Student Presenters: Thomas Wilems, Dan O’Brien
Secondary Readers: Lin Bai
- Park EC, et. al., Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism. EMBO J. 2012 Jan 17. [Epub ahead of print]
- Blum ES, et. al., Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein. Science. 2012 Feb 24;335(6071):970-3.
May 1, 2012
Dan Ory, MD: Niemann-Pick C Disease
Student Presenters: Josiah Gerdts, Sarah DeVos
Secondary Readers: Lauren Walker
- Aqul A, et. al., Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment. J Neurosci. 2011 Jun 22;31(25):9404-13.
- Lopez ME, et. al., Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J Neurosci. 2011 Mar 23;31(12):4367-78.
- Yu T, et. al., Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts. Hum. Mol. Genet. (2012) Epub: April 14, 2012.
January 14, 2010
Course Introduction, Assignment of Student Presentations
January 21, 2010
Marc Diamond, MD: Propagation of protein misfolding in neurodegenerative diseases
Student Presenter(s): Eric Feczko, Dylan McCreedy
- Li JY, et. al., Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation. Nat Med. 2008 May;14(5):501-3.
- Desplats P, et. al., Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5.
- Clavaguera F, et. al., Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009 Jul;11(7):909-13.
- REVIEW: Frost B, Diamond MI. Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci. 2009 Dec 23.
January 28, 2010
Christina Gurnett, MD/PhD: FEVER and epilepsy, a HOT topic
Student Presenter(s): Nithya Jesuraj, Andrea Lui
- Dubé C, et. al., Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain. 2006 Apr;129(Pt 4):911-22.
- Berkovic SF, et. al., De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: a retrospective study. Lancet Neurol. 2006 Jun;5(6):488-92.
- REVIEW: Baulac S, et. al., Fever, genes, and epilepsy. Lancet Neurol. 2004 Jul;3(7):421-30.
February 4, 2010
Robert Baloh, MD: Neurobiology of peripheral nerve disease
Student Presenter(s): Julius Kim, Rachel Smith
- Pennuto M, et. al., Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron. 2008 Feb 7;57(3):393-405.
- Tapinos N, et. al., ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli. Nat Med. 2006 Aug;12(8):961-6.
- REVIEW: Nave KA, Trapp BD. Axon-glial signaling and the glial support of axon function. Annu Rev Neurosci. 2008;31:535-61.
February 11, 2010
John Constantino, MD: Neurobiology of autism
Student Presenter(s): Nithya Jesuraj, Mohammad Maktabi
- Mitchell SR, et. al., Neuroanatomic alterations and social and communication deficits in monozygotic twins discordant for autism disorder. Am J Psychiatry. 2009 Aug;166(8):917-25.
- Chiu PH, et. al., Self responses along cingulate cortex reveal quantitative neural phenotype for high-functioning autism. Neuron. 2008 Feb 7;57(3):463-73.
- Constantino, JN. Autism as a Quantitative Trait. 2010 Oxford Press.
February 18, 2010
Susan Culican, MD/PhD: Critical periods in clinical medicine: visual system development and amblyopia
Student Presenter(s): Dylan McCreedy, Cunguo Wang
- Beck RW. Randomized trial of treatment of amblyopia in children aged 7 to 17 years. Arch. Ophthalmol. Vol 123. Apr 2005.
- A randomized trial of atropine vs patching for treatment of moderate amblyopia in children. Arch. Ophthalmol. Vol 120. Mar 2002.
- REVIEW: Quinn GE, et. al., Recent advances in the treatment of amblyopia. Pediatrics. 2004;113;1800-1802.
February 25, 2010
Charles Zorumski, MD: Psychiatry and brain networks: A view from the hippocampus
Student Presenter(s): Xiaolu Xu, Lixia Jia
- Airan RD, et. al., High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science. 2007 Aug 10;317(5839):819-23.
- Sheline YI, et. al., The default mode network and self-referential processes in depression. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1942-7.
- REVIEW: Price JL & Drevets WC. Neurocircuitry of Mood Disorders. Neuropsychopharmacology. 2010 Jan;35(1):192-216.
March 4, 2010
Bradley Schlaggar, MD/PhD: Tourette Syndrome
Student Presenter(s): Donell Carey, Marie McNeely
- McCairn KW, et. al., The neurophysiological correlates of motor tics following focal striatal disinhibition. Brain 2009 132(8):2125-2138.
- Sowell ER, et. al., Thinning of sensorimotor cortices in children with Tourette syndrome. Nat Neurosci. 2008 Jun;11(6):637-9.
- REVIEW: Ablin RL & Mink JW. Recent advances in Tourette syndrome research. Trends Neurosci. 2006 Mar;29(3):175-82.
March 11, 2010
University Spring Break
March 18, 2010
Christina Lessov-Schlaggar, PhD & Michele Pergadia, PhD: Nicotine Dependence and its Treatment
Student Presenter(s): Jodi Heaps, Xi Lu
- Shiffman S, et. al., Reduction of abstinence-induced withdrawal and craving using high-dose nicotine replacement therapy. Psychopharmacology (Berl). 2006 Mar;184(3-4):637-44.
- Kareken DA, et. al., Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers. Neuroimage. 2010 Mar;50(1):267-76.
- REVIEW: Baker TB, et. al., Addiction motivation reformulated: an affective processing model of negative reinforcement. Psychol Rev. 2004 Jan;111(1):33-51.
- REVIEW: Hyman SE, et. al., Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci. 2006;29:565-98.
- BONUS: Goldstein RZ, et. al., The neurocircuitry of impaired insight in drug addiction. Trends Cogn Sci. 2009 Sep;13(9):372-80.
March 25, 2010
Jonathan Mink, MD/PhD: Dystonia – Clinical Features and Pathophysiology
Student Presenter(s): Andrea Lui, Angie Richmond
- Martella G, et. al., Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. Brain. 2009 Sep;132(Pt 9):2336-49.
- Sciamanna G, et. al., Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia. Neurobiol Dis. 2009 Apr;34(1):133-45.
- REVIEW: Breakefield XO, et. al., The pathophysiological basis of dystonias. Nat Rev Neurosci. 2008 Mar;9(3):222-34.
April 1, 2010
David Brody, MD/PhD: Traumatic Axonal Injury
Student Presenter(s): Jodi Heaps, Yasuko Suzuki
- Gennarelli TA, et. al., Diffuse axonal injury and traumatic coma in the primate. Ann Neurol. 1982 Dec;12(6):564-74.
- Niogi SN, et. al., Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury. Brain. 2008 Dec;131(Pt 12):3209-21.
- REVIEW: Smith DH, et. al., Diffuse axonal injury in head trauma. J Head Trauma Rehabil. 2003 Jul-Aug;18(4):307-16.
April 8, 2010
No Class – Bishop Lecture
April 15, 2010
Terrie Inder, MD: Perinatal brain injury
Student Presenter(s): Marie McNeely, Xiaolu Xu
- Dabydeen L, et. al., High-energy and -protein diet increases brain and corticospinal tract growth in term and preterm infants after perinatal brain injury. Pediatrics. 2008 Jan;121(1):148-56.
- Gozzo Y, et. al., Alterations in neural connectivity in preterm children at school age. Neuroimage. 2009 Nov 1;48(2):458-63.
- REVIEW: Miller SP, Ferriero DM. From selective vulnerability to connectivity: insights from newborn brain imaging. Trends Neurosci. 2009 Sep;32(9):496-505.
- REVIEW: Volpe JJ. The encephalopathy of prematurity–brain injury and impaired brain development inextricably intertwined. Semin Pediatr Neurol. 2009 Dec;16(4):167-78.
April 22, 2010
Gregory Wu, MD/PhD: Multiple Sclerosis: Immune-mediated injury of the central nervous system
Student Presenter(s): Donell Carey, Rachel Smith
- Soulika AM, et. al., Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci. 2009 Nov 25;29(47):14965-79.
- Mathey EK, et. al., Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med. 2007 Oct 1;204(10):2363-72.
- REVIEW: Steinman L, Zamvil SS. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol. 2006 Jul;60(1):12-21.
- REVIEW: Dutta R, Trapp BD. Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology. 2007 May 29;68.
April 29, 2010
Tim Miller, MD/PhD: Understanding Amyotrophic Lateral Sclerosis
Student Presenter(s): Yasuko Suzuki, Xi Lu
- Yamanaka K et al, Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci. 2008 Mar;11(3):251-3.
- Kwiatkowski TJ Jr et al, Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009 Feb 27;323(5918):1205-8.
- Vance C et al, Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science. 2009 Feb 27;323(5918):1208-11.
- REVIEW: Lagier-Tourenne & Cleveland. Rethinking ALS: the FUS about TDP-43. Cell. 2009 Mar 20;136(6):1001-4. Review.
- REVIEW: Rothstein JD. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol. 2009 Jan;65.
May 6, 2010
Alex Evers, MD: Neurobiology of sedation
Student Presenter(s): Eric Feczko, Mohammad Maktabi
- Pang DS et al., An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17546-51.
- Nelson LE et al., The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci. 2002 Oct;5(10):979-84.
- REVIEW: Franks NP. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci. 2008 May;9(5):370-86.