Clocks & Sleep Club
Organizers: Erik Herzog, Paul Taghert
- September 8, 2023: Selma Masri (University of California, Irvine) “Dissecting the role of the circadian clock in cancer”
- October 6, 2023
- Linda Jiameng Sun (DeBosch lab, WashU Pediatrics) “Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock”
- Li-Feng Jiang-Xie (Kipnis lab, WashU Pathology & Immunology) “The Self-Cleansing Brain and Ontogeny of Sleep”
- November 3, 2023
- Maria Gonzalez (Herzog lab, WashU Biology) “Circadian rhythms and brain cancer- leveraging biological clocks to improve clinical treatment”
- Aidan Schneider (Hengen lab, WashU Biology) “The Sleep Signature: A Disentangled State in Each Neuron”
- December 8, 2023
- Ashish Sharma (Musiek lab, WashU Neurology) “Jetlag and neurodegeneration: Impact of circadian desynchrony on pathogenesis of Alzheimer’s disease”
- Chi-Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Alternative light pathway – circuit and function of IGL NPY neurons”
- January 12, 2024
- Lizzie Tilden (Y. Chen lab, WashU Neuroscience) “Temporal dynamics of Protein Kinase A across the sleep-wake cycle”
- Amanda Cimino (Guilak lab, WashU Orthopaedic Surgery) “Synthetic gene circuits for autonomously regulated circadian-driven drug delivery to target flares in arthritis”
- February 9, 2024
- Samira Parhizkar (Holtzman lab, WashU Neurology) “Lemborexant, a dual orexin receptor antagonist, ameliorates tau-mediated sleep loss and neurodegeneration”
- Collin Nadarajah (Musiek lab, WashU Neurology) “Circadian regulation of complement C4: implications for Alzheimer’s Disease”
- April 12, 2024
- Kyohei Tokizane (Imai lab, WashU Developmental Biology) “The Role of Ppp1r17 Neurons in the Dorsomedial Hypothalamus in Mammalian Aging and Longevity Control”
- Matthew Rosengart (WashU Surgery) “Light in Critical Illness”
- May 10, 2024
- Jackie Pelham (Holehouse lab, WashU Biochemistry & Molecular Biophysics) “Proteoform plasticity modulates the Neurospora core clock temperature response”
- Jeff Haspel (WashU Medicine) “Organ donor clocks in transplantation acceptance: A proposal”
- VIRTUAL June 14, 2024: Carrie Partch (University of California, Santa Cruz)
Organizers: Erik Herzog, Paul Taghert
- September 9, 2022
- Keenan Bates (Herzog lab, WashU Biology) “Circadian Rhythms in the Fetus and Placenta Develop and Change during Gestation”
- Jesse Keller (WashU Medicine) “CLOCKing in: When is the best time for Immune Checkpoint Inhibitors to Show Up for Work?”
- *Special Seminar September 21, 2022
2:00p, Wohl Auditorium
Jointly hosted by COBRAS and the Hope Center Clocks & Sleep Club- Erin Gibson (Stanford University) “A New Wrap for Myelin: A potential role for oligodendroglia in sleep”
- View recording
- October 14, 2022
- Wangchao (Iverchao) Xu (Kipnis lab, WashU Pathology & Immunology) “A glia-microbiota-neuronal axis that modulates sleep”
- Samira Parhizkar (Holtzman lab, WashU Neurology) “Dual orexin receptor inhibition markedly ameliorates APOE4 driven microglial reactivity and tau-mediated neurodegeneration”
- November 11, 2022
- Kayla Paynter (BJC Healthcare) “Sleep Preservation for the Inpatient Setting”
- Talk Postponed –Jason Dude (Ju lab, WashU Neurology) “Can Sleep-EEG features predict cognitive performance and Alzheimer disease pathology?”
- December 9, 2022
- Jennifer Lawrence (Musiek lab, WashU Neurology) “Light drives time-of-day differences in inflammatory blood-brain barrier disruption”
- Chin-Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Intergeniculate leaflet – the role of an indirect retinal pathway on non-imaging forming visual behaviors”
- January 13, 2023
- Jackie Pelham (Holehouse lab, WashU Biochemistry and Molecular Biophysics) “Deciphering the Contributions of Protein Disorder to the Circadian Clock Repressors”
- Jason Dude (Ju lab, WashU Neurology) “Can Sleep-EEG features predict cognitive performance and Alzheimer disease pathology?”
- February 10, 2023
- Yifan Xu (Hengen lab, WashU Biology) “Sleep restores an optimal computational regime in cortical networks”
- Christine Merlin (Texas A & M University) “Circadian clock regulation of monarch butterfly seasonal migration”
- March 10, 2023
- Melanie Ford (Shaw lab, WashU Neuroscience) “Sleep Deprivation, Sleep Fragmentation and Social Jet Lag increase temperature preference in Drosophila”
- Aaron Cone (Norris lab, WashU Anesthesiology), Spencer Blackwood (Lee lab, WashU Neurology) with a brief introduction by Eric Landsness (WashU Neurology)
“Population of medial preoptic area neurons that regulate metabolism, temperature and arousal”
- April 14, 2023
- Huram Mok (Haspel lab, WashU Medicine) “Biological Rhythms in Host Responses to Coronavirus”
- Lizzie Tilden (Y Chen lab, WashU Neuroscience) “Temporal dynamics of Protein Kinase A across the sleep-wake cycle”
- May 12, 2023
- Eric Landsness (WashU Neurology) “Local changes in sleep slow oscillations after stroke”
- Ben Palanca (WashU Anesthesiology) “Stories on Slow Wave Sleep”
- Special Seminar June 27, 2023: Ryosuke Enoki (National Institute for Physiological Sciences, Japan) – “Circadian Rhythms under Cold Temperature in Pacemaking Neurons”
Organizers: Erik Herzog, Paul Taghert
September 17, 2021
- Horacio de la Iglesia (University of Washington) “A fear-entrained oscillator in the mouse”
- Anna Damato (Herzog lab, WashU Biology) “Circadian rhythms in glioblastoma and its treatment”
October 8, 2021
- Chanung Wang (Holtzman lab, WashU Neurology) “Identifying interactions between Sleep, APOE genotype, and Neuritic plaque tau pathology”
- Alexxai Kravitz (WashU Psychiatry) “Internet-of-Things monitoring of rodent circadian and sleep behaviors”
November 19, 2021
- Chi-Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Intergeniculate leaflet pathways and non-image-forming visual behaviors”
- Brendan Lucey** (WashU Neurology) “Acute effect of suvorexant on CSF Alzheimer disease biomarkers”
**COBRAS Neurodegeneration Working Group
December 10, 2021
- Kristen Edgeworth (Nusinow lab, Danforth Plant Science Center) “Investigating the circadian regulation of lipid metabolism in Arabidopsis thaliana”
- Peinan Zhao** (WashU Obstetrics and Gynecology) “A new method for analyzing actigraphy circadian rhythm data”
**representing the COBRAS Working Group on Human Technology
- January 14, 2022
- Patrick Sheehan (Musiek lab, WashU Neurology) “Astrocytic circadian reprogramming in aging and Alzheimer’s Disease”
- Aidan Schneider (Hengen lab, WashU Biology) “Circuit-specific flickering of sleep and wake in freely-behaving mice”
- February 11, 2022
- Aaron Norris (WashU Anesthesiology) “Getting to the KOR of Torpor and Thermal Regulatory Neural Circuits in the Hypothalamus”
- Fang Gao (Chen lab, WashU Anesthesiology) “An update on the neural circuit of contagious itch”
- March 11, 2022
- Lei Gao (Massachusetts General Hospital) “Sleep/circadian rhythms: Novel insights into delirium risk during hospitalization”
– Faculty hosts: Ben Palanca, Kendall Smith (WashU Anesthesiology), representing COBRAS Acute/Critical Illness Working Group - Caroline Hoyniak (WashU Psychiatry) “Maternal sleep and circadian disruption during pregnancy and infant outcomes”
– Faculty hosts: Amy Licis (WashU Neurology) and Sarah England (WashU Obstetrics & Gynecology), representing COBRAS Development Working Group
- Lei Gao (Massachusetts General Hospital) “Sleep/circadian rhythms: Novel insights into delirium risk during hospitalization”
- April 8, 2022
- Tracey Hermanstyne (WashU Developmental Biology) and Nien-Du Yang (Nerbonne lab, WashU Medicine) “The Physiological Role of Sub-threshold Ionic Conductances in the Regulation of SCN Neuronal Excitability”
- Jeff Haspel and Huram Mok (WashU Medicine) “Circadian Reprogramming in Chronic Airway Disease”
– Representing COBRAS Inflammation & Immunology Working Group
- May 6, 2022
- Lizzie Tilden (Chen lab, WashU Neuroscience) “Dynamics of intracellular signals during sleep behavior”
- Bettina Mittendorfer and Sarah Farabi (WashU Medicine)
– Representing COBRAS Cardiometabolic Working Group
- June 10, 2022
- Brendan Lucey (WashU Neurology) and Erik Herzog (WashU Biology)
– Representing COBRAS Implementation/Policy Outreach Working Group - Bishan Bhattari (Colonna lab, WashU Pathology & Immunology) “Investigating the role of Rev-Erbs in ILCs”
- Brendan Lucey (WashU Neurology) and Erik Herzog (WashU Biology)
Organizers: Erik Herzog, Dmitri Nusinow and Paul Taghert
- June 5, 2020: Keenan Bates (Herzog lab, WashU Biology) “In Utero Imaging of Clock Gene Expression Reveals the Development of the Embryonic Circadian Clock”
- July 10, 2020: Chi Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Investigate the role of intergeniculate leaflet in circadian rhythm”
- August 7, 2020:
- Paul Taghert (WashU Dept. of Neuroscience) “On the timing of GPCR signaling in circadian physiology”
- Nithya Chennupati (Ju lab, WashU Neurology) “Race effects on sleep, circadian function, and Alzheimer Disease biomarkers”
- September 4, 2020:
- Samira Parhizkar (Holtzman lab, WashU Neurology) “Sleep Disruption Exacerbates and Prolongs the Inflammatory Response to Traumatic Brain Injury”
- Jeffrey Haspel (WashU Medicine) “What’s out there about circadian rhythms and COVID-19?”
- September 11, 2020: Erik Herzog (WashU Biology), Michael Hughes (WashU Medicine), Peinan Zhao (WashU Obstetrics/Gynecology) “A Workshop: Time series analysis and measures from wearable devices”
- October 9, 2020:
- Melvin King (Musiek lab, WashU Neurology) “Central vs. peripheral clocks in neurodegeneration”
- Lara Pferdehirt (Guilak lab, WashU Orthopaedic Surgery) “Turning back the clock on cartilage damage”
- November 6, 2020:
- Maria Sorkin (Nusinow lab, Danforth Plant Science Center) “A Proteomic Approach Discovers a Putative Cold Temperature Regulatory Complex in the Arabidopsis Circadian Clock”
- Eric Landsness (WashU Neurology) “Deep Learning of Non-Invasive Calcium Imaging Reliably Classifies Sleep States in Mice”
- December 4, 2020:
- Geraldine Kress (WashU Neurology) “A journal club discussion on two recent articles about the circadian system and sleep”
- Suggested Readings:
- “Circadian VIPergic Neurons of the Suprachiasmatic Nuclei Sculpt the Sleep-Wake Cycle” Neuron 2020
- “Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations” Nature Communications 2020
- Ronald McCarthy (England lab, WashU Obstetrics & Gynecology) “Association between daily melatonin and cortisol rhythms and risk of preterm birth”
- Geraldine Kress (WashU Neurology) “A journal club discussion on two recent articles about the circadian system and sleep”
- January 8, 2021:
- Chao Zhou (WashU Biomedical Engineering) “Characterizing the influence of a circadian clock gene, Cry, on Drosophila heart function using optical coherence microscopy”
- Jeff Jones (Herzog lab, WashU Biology) “Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids”
- February 12, 2021:
- Michael Fitzpatrick (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Homeostatic Plasticity in Non-Image-Forming Vision”
- Paul Shaw (WashU Dept. of Neuroscience)
- March 5, 2021:
- Jeffrey Haspel (WashU Medicine)
- Dmitri Nusinow (Danforth Plant Science Center) “A circadian clock in a nonphotosynthetic prokaryote” Science Advances (2021)
- April 2, 2021:
- Bishan Bhattarai (Colonna lab, WashU Pathology & Immunology) “Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development”
- Samira Parhizkar (Holtzman lab, WashU Neurology) “Deciphering the role of sleep on neuroinflammation in Alzheimer’s disease”
- April 30, 2021:
- Jiyeon Lee (Musiek lab, WashU Neurology) “Sex-specific effects of microglial REV-ERB-alpha on Tauopathy”
- Lara Pferdehirt (Guilak lab, WashU Orthopaedic Surgery) “Synthetic Biology Applications for Chronotherapy and Circadian Rhythms”
Organizers: Erik Herzog, Dmitri Nusinow and Paul Taghert
- September 6, 2019:
- Jeffrey Haspel (WashU Medicine)“Circadian signatures in chronic lung disease”
- Chi-Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Organization and functions of the intergeniculate leaflet”
- October 4, 2019:
- Celia McKee (Musiek lab, WashU Dept. of Neurology) “An Update of Circadian Modulation of Protein Degradation”
- Dmitri Nusinow (Donald Danforth Plant Science Center) “Protein interactions within the plant circadian clock”
- October 16, 2019: Boris Kotchoubey (University of Tübingen) “Sleep in disorders of consciousness”
- November 1, 2019:
- Geraldine Kress (WashU Neurology) “Circadian Modulation of Hippocampal Function during Alzheimer’s Disease Pathogenesis”
- Paul Taghert (WashU Dept. of Neuroscience) “Hub-organized parallel circuits of central circadian pacemaker neurons for visual photoentrainment in Drosophila”
- December 6, 2019:
- Farshid Guilak (WashU Orthopaedic Surgery) “Designer stem cells for synthetic (chrono)biology: A joint venture”
- Chanung Wang (Holtzman lab, WashU Neurology) “‘Identifying interactions between Sleep, APOE genotype, and Neuritic plaque tau pathology”
- January 10, 2020:
- Jeff Jones (Herzog lab, WashU Biology) “Circadian circuits underlying daily rhythms in corticosterone release”
- Qianli Wang (Colonna lab, WashU Pathology & Immunology) “The roles of REV-ERBα and circadian rhythm in intestinal type 3 innate lymphoid cells”
- January 31, 2020:
- Thomas Jones: “To feed or not to feed: chronoecology of aggression in spiders”
- Darrell Moore: “Chronoecology: how the honey bee time memory functions within the ephemeral environment”
- February 7, 2020:
- Fang Gao (Chen lab, WashU Anesthesiology) “Neural circuit of contagious itch: an update”
- Eric Landsness (Lee lab, WashU Neurology) “Local slow wave sleep and stroke”
- March 6, 2020:
- Anna Damato (Herzog lab, WashU Biology) “Circadian rhythms in glioblastoma tumors and effects of timed chemotherapy”
- Michael Fitzpatrick (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Homeostatic Plasticity in Retinal Illuminance-Detection Circuits”
- CANCELLED – April 3, 2020: Chao Zhou (WashU Biomedical Engineering), Musiek lab (WashU Neurology)
- POSTPONED – April 10, 2020: Ketema Paul (University of California, Los Angeles)
- CANCELLED – April 24, 2020: Erin Gibson (Stanford University) “Circadian modulation of oligodendroglial lineage cells and myelination in development and disease”
- CANCELLED – May 1, 2020: Holtzman lab (WashU Neurology), Nusinow lab (Donald Danforth Plant Science Center)