Clocks & Sleep Club

2023 Fall Schedule

Organizers: Erik Herzog, Paul Taghert

  • September 8, 2023: Selma Masri (University of California, Irvine) “Dissecting the role of the circadian clock in cancer”
  • October 6, 2023
    • Linda Jiameng Sun (DeBosch lab, WashU Pediatrics) “Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock”
    • Li-Feng Jiang-Xie (Kipnis lab, WashU Pathology & Immunology) “The Self-Cleansing Brain and Ontogeny of Sleep”
  • November 3, 2023
    • Maria Gonzalez (Herzog lab, WashU Biology) “Circadian rhythms and brain cancer- leveraging biological clocks to improve clinical treatment”
    • Aidan Schneider (Hengen lab, WashU Biology) “The Sleep Signature: A Disentangled State in Each Neuron”
  • December 8, 2023
    • Ashish Sharma (Musiek lab, WashU Neurology) “Jetlag and neurodegeneration: Impact of circadian desynchrony on pathogenesis of Alzheimer’s disease”
    • Chi-Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Alternative light pathway – circuit and function of IGL NPY neurons”
2022/2023 Schedule

Organizers: Erik Herzog, Paul Taghert

  • September 9, 2022
    • Keenan Bates (Herzog lab, WashU Biology) “Circadian Rhythms in the Fetus and Placenta Develop and Change during Gestation”
    • Jesse Keller (WashU Medicine) “CLOCKing in: When is the best time for Immune Checkpoint Inhibitors to Show Up for Work?”
  • *Special Seminar September 21, 2022
    2:00p, Wohl Auditorium
    Jointly hosted by COBRAS and the Hope Center Clocks & Sleep Club
    • Erin Gibson (Stanford University) “A New Wrap for Myelin: A potential role for oligodendroglia in sleep”
    • View recording
  • October 14, 2022
    • Wangchao (Iverchao) Xu (Kipnis lab, WashU Pathology & Immunology)  “A glia-microbiota-neuronal axis that modulates sleep”
    • Samira Parhizkar (Holtzman lab, WashU Neurology) “Dual orexin receptor inhibition markedly ameliorates APOE4 driven microglial reactivity and tau-mediated neurodegeneration”
  • November 11, 2022
    • Kayla Paynter (BJC Healthcare) “Sleep Preservation for the Inpatient Setting”
    • Talk Postponed –Jason Dude (Ju lab, WashU Neurology) “Can Sleep-EEG features predict cognitive performance and Alzheimer disease pathology?”
  • December 9, 2022
    • Jennifer Lawrence (Musiek lab, WashU Neurology) “Light drives time-of-day differences in inflammatory blood-brain barrier disruption”
    • Chin-Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Intergeniculate leaflet – the role of an indirect retinal pathway on non-imaging forming visual behaviors”
  • January 13, 2023
    • Jackie Pelham (Holehouse lab, WashU Biochemistry and Molecular Biophysics) “Deciphering the Contributions of Protein Disorder to the Circadian Clock Repressors”
    • Jason Dude (Ju lab, WashU Neurology) “Can Sleep-EEG features predict cognitive performance and Alzheimer disease pathology?”
  • February 10, 2023
    • Yifan Xu (Hengen lab, WashU Biology) “Sleep restores an optimal computational regime in cortical networks”
    • Christine Merlin (Texas A & M University) “Circadian clock regulation of monarch butterfly seasonal migration”
  • March 10, 2023
    • Melanie Ford (Shaw lab, WashU Neuroscience) “Sleep Deprivation, Sleep Fragmentation and Social Jet Lag increase temperature preference in Drosophila”
    • Aaron Cone (Norris lab, WashU Anesthesiology), Spencer Blackwood (Lee lab, WashU Neurology) with a brief introduction by Eric Landsness (WashU Neurology)
      “Population of medial preoptic area neurons that regulate metabolism, temperature and arousal”
  • April 14, 2023
    • Huram Mok (Haspel lab, WashU Medicine) “Biological Rhythms in Host Responses to Coronavirus”
    • Lizzie Tilden (Y Chen lab, WashU Neuroscience) “Temporal dynamics of Protein Kinase A across the sleep-wake cycle”
  • May 12, 2023
    • Eric Landsness (WashU Neurology) “Local changes in sleep slow oscillations after stroke”
    • Ben Palanca (WashU Anesthesiology) “Stories on Slow Wave Sleep”
  • Special Seminar June 27, 2023: Ryosuke Enoki (National Institute for Physiological Sciences, Japan) – “Circadian Rhythms under Cold Temperature in Pacemaking Neurons”
2021/2022 Schedule

Organizers: Erik Herzog, Paul Taghert

September 17, 2021

  • Horacio de la Iglesia (University of Washington) “A fear-entrained oscillator in the mouse”
  • Anna Damato (Herzog lab, WashU Biology) “Circadian rhythms in glioblastoma and its treatment”

October 8, 2021

  • Chanung Wang (Holtzman lab, WashU Neurology) “Identifying interactions between Sleep, APOE genotype, and Neuritic plaque tau pathology”
  • Alexxai Kravitz (WashU Psychiatry) “Internet-of-Things monitoring of rodent circadian and sleep behaviors”

November 19, 2021

  • Chi-Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Intergeniculate leaflet pathways and non-image-forming visual behaviors”
  • Brendan Lucey** (WashU Neurology) “Acute effect of suvorexant on CSF Alzheimer disease biomarkers”
    **COBRAS Neurodegeneration Working Group

December 10, 2021

  • Kristen Edgeworth (Nusinow lab, Danforth Plant Science Center) “Investigating the circadian regulation of lipid metabolism in Arabidopsis thaliana”
  • Peinan Zhao** (WashU Obstetrics and Gynecology)A new method for analyzing actigraphy circadian rhythm data”
    **representing the COBRAS Working Group on Human Technology
  • January 14, 2022
    • Patrick Sheehan (Musiek lab, WashU Neurology) “Astrocytic circadian reprogramming in aging and Alzheimer’s Disease”
    • Aidan Schneider (Hengen lab, WashU Biology) “Circuit-specific flickering of sleep and wake in freely-behaving mice”
  • February 11, 2022
    • Aaron Norris (WashU Anesthesiology) “Getting to the KOR of Torpor and Thermal Regulatory Neural Circuits in the Hypothalamus”
    • Fang Gao (Chen lab, WashU Anesthesiology) “An update on the neural circuit of contagious itch”
  • March 11, 2022
    • Lei Gao (Massachusetts General Hospital) “Sleep/circadian rhythms: Novel insights into delirium risk during hospitalization”
      – Faculty hosts: Ben Palanca, Kendall Smith (WashU Anesthesiology), representing COBRAS Acute/Critical Illness Working Group
    • Caroline Hoyniak (WashU Psychiatry) “Maternal sleep and circadian disruption during pregnancy and infant outcomes” 
      – Faculty hosts: Amy Licis (WashU Neurology) and Sarah England (WashU Obstetrics & Gynecology), representing COBRAS Development Working Group
  • April 8, 2022
    • Tracey Hermanstyne (WashU Developmental Biology) and Nien-Du Yang (Nerbonne lab, WashU Medicine) “The Physiological Role of Sub-threshold Ionic Conductances in the Regulation of SCN Neuronal Excitability”
    • Jeff Haspel and Huram Mok (WashU Medicine) “Circadian Reprogramming in Chronic Airway Disease”
      – Representing COBRAS Inflammation & Immunology Working Group
  • May 6, 2022
    • Lizzie Tilden (Chen lab, WashU Neuroscience) “Dynamics of intracellular signals during sleep behavior”
    • Bettina Mittendorfer and Sarah Farabi (WashU Medicine)
      – Representing COBRAS Cardiometabolic Working Group
  • June 10, 2022
    • Brendan Lucey (WashU Neurology) and Erik Herzog (WashU Biology)
      – Representing COBRAS Implementation/Policy Outreach Working Group
    • Bishan Bhattari (Colonna lab, WashU Pathology & Immunology) “Investigating the role of Rev-Erbs in ILCs”
2020/2021 Schedule

Organizers: Erik Herzog, Dmitri Nusinow and Paul Taghert

  • June 5, 2020: Keenan Bates (Herzog lab, WashU Biology) “In Utero Imaging of Clock Gene Expression Reveals the Development of the Embryonic Circadian Clock”
  • July 10, 2020: Chi Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Investigate the role of intergeniculate leaflet in circadian rhythm”
  • August 7, 2020:
    • Paul Taghert (WashU Dept. of Neuroscience) “On the timing of GPCR signaling in circadian physiology”
    • Nithya Chennupati (Ju lab, WashU Neurology) “Race effects on sleep, circadian function, and Alzheimer Disease biomarkers”
  • September 4, 2020:
  • September 11, 2020: Erik Herzog (WashU Biology), Michael Hughes (WashU Medicine), Peinan Zhao (WashU Obstetrics/Gynecology) “A Workshop: Time series analysis and measures from wearable devices”
  • October 9, 2020:
    • Melvin King (Musiek lab, WashU Neurology) “Central vs. peripheral clocks in neurodegeneration”
    • Lara Pferdehirt (Guilak lab, WashU Orthopaedic Surgery) “Turning back the clock on cartilage damage”
  • November 6, 2020:
    • Maria Sorkin (Nusinow lab, Danforth Plant Science Center) “A Proteomic Approach Discovers a Putative Cold Temperature Regulatory Complex in the Arabidopsis Circadian Clock​”
    • Eric Landsness (WashU Neurology) “Deep Learning of Non-Invasive Calcium Imaging Reliably Classifies Sleep States in Mice”
  • December 4, 2020:
  • January 8, 2021:
    • Chao Zhou (WashU Biomedical Engineering) “Characterizing the influence of a circadian clock gene, Cry, on Drosophila heart function using optical coherence microscopy”
    • Jeff Jones (Herzog lab, WashU Biology) “Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids”
  • February 12, 2021:
    • Michael Fitzpatrick (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Homeostatic Plasticity in Non-Image-Forming Vision”
    • Paul Shaw (WashU Dept. of Neuroscience)
  • March 5, 2021:
  • April 2, 2021:
    • Bishan Bhattarai (Colonna lab, WashU Pathology & Immunology) “Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development”
    • Samira Parhizkar (Holtzman lab, WashU Neurology) “Deciphering the role of sleep on neuroinflammation in Alzheimer’s disease”
  • April 30, 2021:
    • Jiyeon Lee (Musiek lab, WashU Neurology) “Sex-specific effects of microglial REV-ERB-alpha on Tauopathy”
    • Lara Pferdehirt (Guilak lab, WashU Orthopaedic Surgery) “Synthetic Biology Applications for Chronotherapy and Circadian Rhythms”
2019/2020 Schedule

Organizers: Erik Herzog, Dmitri Nusinow and Paul Taghert

  • September 6, 2019:
    • Jeffrey Haspel (WashU Medicine)“Circadian signatures in chronic lung disease”
    • Chi-Chan Lee (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Organization and functions of the intergeniculate leaflet”
  • October 4, 2019:
    • Celia McKee (Musiek lab, WashU Dept. of Neurology) “An Update of Circadian Modulation of Protein Degradation”
    • Dmitri Nusinow (Donald Danforth Plant Science Center) “Protein interactions within the plant circadian clock”
  • October 16, 2019: Boris Kotchoubey (University of Tübingen) “Sleep in disorders of consciousness”
  • November 1, 2019:
  • December 6, 2019:
    • Farshid Guilak (WashU Orthopaedic Surgery) “Designer stem cells for synthetic (chrono)biology: A joint venture”
    • Chanung Wang (Holtzman lab, WashU Neurology) “‘Identifying interactions between Sleep, APOE genotype, and Neuritic plaque tau pathology”
  • January 10, 2020:
    • Jeff Jones (Herzog lab, WashU Biology) “Circadian circuits underlying daily rhythms in corticosterone release”
    • Qianli Wang (Colonna lab, WashU Pathology & Immunology) “The roles of REV-ERBα and circadian rhythm in intestinal type 3 innate lymphoid cells”
  • January 31, 2020:
    • Thomas Jones: “To feed or not to feed: chronoecology of aggression in spiders”
    • Darrell Moore: “Chronoecology: how the honey bee time memory functions within the ephemeral environment”
  • February 7, 2020:
    • Fang Gao (Chen lab, WashU Anesthesiology) “Neural circuit of contagious itch: an update”
    • Eric Landsness (Lee lab, WashU Neurology) “Local slow wave sleep and stroke”
  • March 6, 2020:
    • Anna Damato (Herzog lab, WashU Biology) “Circadian rhythms in glioblastoma tumors and effects of timed chemotherapy”
    • Michael Fitzpatrick (Kerschensteiner lab, WashU Ophthalmology & Visual Sciences) “Homeostatic Plasticity in Retinal Illuminance-Detection Circuits”
  • CANCELLED – April 3, 2020: Chao Zhou (WashU Biomedical Engineering), Musiek lab (WashU Neurology)
  • POSTPONED – April 10, 2020: Ketema Paul (University of California, Los Angeles)
  • CANCELLED – April 24, 2020: Erin Gibson (Stanford University) “Circadian modulation of oligodendroglial lineage cells and myelination in development and disease”
  • CANCELLED – May 1, 2020: Holtzman lab (WashU Neurology), Nusinow lab (Donald Danforth Plant Science Center)