Neurogenetics & Transcriptomics Group

2022/2023 Schedule

Organizers: Gabriel Haller, Carlos Cruchaga

  • October 14, 2022*: Gabriel Haller (WashU Neurosurgery)
  • November 4, 2022: Dan Western (Cruchaga lab, WashU Psychiatry) “Large-scale cerebrospinal fluid pQTL analysis identifies novel proteins causal for Alzheimer’s disease”
  • December 2, 2022: Reshma Bhagat (Karch lab, WashU Psychiatry) “Role of long non-coding RNAs in Tauopathy”
  • January 6, 2023: Vishnu Muraleedharan Saraswathy (Mokalled lab, WashU Developmental Biology) “Single-cell transcriptomics reveal potent pro-regenerative populations in the adult spinal cord”
  • February 3, 2023: Shujuan Zhao (Jin and Kahle labs, WashU Genetics and Harvard University) “Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations”
  • March 3, 2023: Mikhail Berezin (WashU Radiology) “Understanding oxaliplatin induced neurotoxicity from RNA-seq data”
  • VIRTUALApril 7, 2023: Aleksandra (Sashka) Beric (Ibanez lab, WashU Psychiatry) “Small RNAs, short but mighty: the unknown players in AD pathobiology”
  • May 5, 2023: Saligrama lab, WashU Neurology
    • Julia Bals“Compartment-specific immune responses to 𝛼-Synuclein”
    • Chandrani Thakur“Clonal evolution, phenotype, and distribution of self-antigen specific CD4 T cells in experimental autoimmune encephalomyelitis”
2021/2022 Schedule

Organizers: Gabriel Haller, Carlos Cruchaga

  • September 3, 2021: Yun Ju Sung (WashU Psychiatry) “Proteomic profiling identified plasma biomarkers for SARS-CoV-2 infection”
  • October 15, 2021: Laura Ibanez (WashU Psychiatry) “Circular RNA detection identifies circPSEN1 alterations in brain specific to Autosomal Dominant Alzheimer Disease”
  • November 5, 2021: Miguel Minaya (Karch lab, WashU Psychiatry) “Impact of MAPT mutations on transcriptomic signatures of FTLD brains and patient-derived pluripotent cell models”
  • December 3, 2021: Jiayang Chen (Dougherty lab, WashU Genetics) “Unravel neurodevelopmental disorders related MYT1L’s functions in vivo”
  • January 7, 2022: Chengcheng Li (Weihl lab, WashU Neurology) “Deep mutational screening of proteins associated with LGMD”
  • February 4, 2022: Anthony Wang (Petti lab, WashU Neurosurgery), Tom Barrett (WashU Otolaryngology)
    • Anthony Wang: “Single Cell Profiling of Human Dura and Meningioma Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response”
    • Tom Barrett“Single-cell analysis of vestibular schwannoma”
  • March 4, 2022: Shiming Chen (WashU Ophthalmology & Visual Sciences) “Understanding CRX-linked blinding diseases”
  • April 1, 2022: Joseph Ippolito (WashU Radiology) “Elucidating sex differences in glucose and amino acid metabolism in glioblastoma”
  • May 6, 2022: Tristan Li (WashU Neuroscience) “Microglial heterogeneity in development, aging and disease”
2020/2021 Schedule

Organizers: Gabriel Haller, Carlos Cruchaga

  • July 2, 2020: Peter Jin (WashU Genetics) “Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus”
  • August 7, 2020: Miguel Minaya, Shih Feng You (Karch lab, WashU Psychiatry)
    • Miguel Minaya: “Increase in 4R-Tau Isoforms using Antisense Oligonucleotides (ASOs) Treatment Accelerated the Maturation of hiPSC-Derived Cortical Neurons and Transformed them into a Promising Model for Studying Primary Tauopathies”
    • Shih Feng You: “Multi-omics approaches reveal a link between the MS4A gene loci, TREM2 and microglia function”
  • September 4, 2020: Wei-Le Wang, Shoutang Wang (Colonna lab, WashU Pathology & Immunology)
    • Wei-Le Wang: Micromanager of Microglia: Exploring the role of MicroRNA-142 in microglial development and function”
    • Shoutang Wang: “Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model”
  • October 9, 2020: Sharlee Climer (University of Missouri, St. Louis) “Protein patterns associated with late-onset Alzheimer disease”
  • November 6, 2020: Victoria Fernandez (WashU Psychiatry) “Dissecting Alzheimer Disease using multiple omic datasets”
  • December 4, 2020: Laura Ibañez (WashU Psychiatry) “Cell-free RNA transcripts in plasma can predict Alzheimer disease before symptom onset”
  • January 8, 2021: Hao Chen (Kim lab, WashU Neurosurgery) “Protein de-ubiquitination in neurodevelopment and disease”
  • February 5, 2021: Logan Brase (Harari lab, WashU Psychiatry) “Molecular Characterization of Autosomal Dominant and Sporadic Alzheimer Disease Brains Leveraging Single Nuclei RNA-Sequencing”
  • March 5, 2021: Pat McAllister/Albert Isaacs (Limbrick/McAllister lab, WashU Neurosurgery)
  • April 2, 2021: Guoyan Zhao (WashU Dept of Neuroscience)“Astrocyte subpopulation-specific contribution to Aβ pathology, neuroinflammation and neurodegeneration”
  • May 7, 2021: Naeimeh Tayebi (Gurnett lab, WashU Neurology) “Deep Mutational scanning for neurogenetic disorders”
2019/2020 Schedule

Organizers: Carlos Cruchaga, Christina Gurnett

  • September 10, 2019: William Buchser (WashU Genetics) “Large Scale Functional Genomics for Neurons and Subtle Phenotypes”
  • October 8, 2019: Chengran Yang (Cruchaga lab, WashU Psychiatry) “Multi-tissue proteomic analyses in AD”
  • CANCELLED – November 12, 2019: Ashley Quiggle (Gurnett lab, WashU Neurology and Haller lab, WashU Neurosurgery)
  • November 26, 2019: Nikolaos Mellios (University of New Mexico Health Sciences Center) “A neuropsychiatric disease-associated circular RNA controls synaptic function and cognition”
  • December 10, 2019: Celeste Karch (WashU Psychiatry)
  • January 14, 2020: Oscar Harari (WashU Psychiatry) “Single-nuclei in human brain to develop a molecular and cellular atlas of Neurodegeneration”
  • February 11, 2020: Gabriel Haller (WashU Neurosurgery) “Human Genetics of Chiari malformation”
  • March 10, 2020: Darshan Sapkota (Dougherty lab, WashU Genetics) “TRAP-RF, a novel neurogenomics tool, identifies atypical protein variants involved in brain function and disease”
  • CANCELLED – April 14, 2020: Ken Smith (Climer lab, University of Missouri, St. Louis)
  • CANCELLED – May 12, 2020: Victoria Fernandez (Cruchaga lab, WashU Psychiatry) “AD next Gene Sequencing and multi-omics”