New: Lipid Metabolism

Organizer: Anil Cashikar Read More


Lipid metabolism in the brain has been identified as highly impactful for neuroinflammation. It is well known that apolipoprotein E (ApoE), the main lipid carrier protein in the brain, is the biggest risk factor for Alzheimer’s disease. Dysfunction in lipid efflux and lipid storage pathways appear to be strongly associated with inflammatory activation of glia. Targeting specific aspects of the brain lipid metabolism may offer therapeutic opportunities. The new Lipid Metabolism Research Group gathers those who have made pioneering contributions in understanding the connection between lipid metabolism, immune activation and neurological/psychiatric disorders, and others who would like to know more about these contributions, better understand the role of lipid metabolism in health and disease, exchange ideas, methodology and reagents and explore opportunities for identification of existing resources and development of new resources.

Organizers/Contact Information

For additional information about the Lipid Metabolism Group, please contact the faculty organizer Anil Cashikar or the Hope Center.

2022 Schedule, Lipid Metabolism Group

2nd Friday of the month
Zoom conference
Work in Progress (WiP) and/or Journal Club (JC)

Zoom links (WUSTL Key required)

  • January 14: Gwendalyn Randolph (WashU Pathology & Immunology) – WiP, JC “Macrophage membrane cholesterol and lipidome in inflammation and host defense”
  • February 11: Michael Strickland (Holtzman lab, WashU Neurology) – WiP “ApoE-Trem2 Axis Impacts Cholesterol Metabolism”
  • March 11: Victoria Ismail (Kast lab, WashU Cell Biology & Physiology) – WiP “The GTPase activity of DFCP1 modulates lipid droplet metabolism”
  • April 8: Clay Semenkovich (WashU Medicine) – WiP “Palmitoylation Cycling and Metabolic Disease”
  • May 13: Yun Chen (Holtzman lab, WashU Neurology) – WiP “Preliminary characterization of the impacts of ApoE3 Christchurch mutation on lipid metabolism and pathology for Alzheimer’s Disease”
  • June 10: Pallavi Chandra (Philips lab, WashU Medicine) “Host-pathogen lipid metabolism during Mycobacterium tuberculosis infection”
  • July 8: Nada Abumrad (WashU Medicine) “Fatty Acids and Cognition”
  • August 12
  • September 9: Irfan Lodhi (WashU Medicine)
  • October 14: Alexandra Litvinchuk (Holtzman lab, WashU Neurology)
  • November 11: David Ford (Saint Louis University)
  • December 9

All meetings are listed on the Office of Neuroscience Research (ONR) Calendar.

Lipid Metabolism Faculty Members

Faculty organizer: Anil Cashikar (WashU Psychiatry)

Affiliated faculty members

Anil Cashikar (WashU Psychiatry)
Jonathan Cooper (WashU Pediatrics)
Carlos Cruchaga (WashU Psychiatry)
Albert (Gus) Davis (WashU Neurology)
Abhinav Diwan (WashU Medicine)
Alex Evers (WashU Anesthesiology)
David Ford (Saint Louis University)
Song Hu (WashU Biomedical Engineering)
Laura Ibanez (WashU Psychiatry)
Joseph Ippolito (WashU Radiology)
Celeste Karch (WashU Psychiatry)
David Kast (WashU Cell Biology & Physiology)
Erik Musiek (WashU Neurology)
Jennifer Philips (WashU Medicine)
Gwendalyn Randolph (WashU Pathology & Immunology)
Daniela Salvemini (Saint Louis University)
Clay Semenkovich (WashU Medicine)
Ananth Vellimana (WashU Neurosurgery)