Monday Noon Seminars

About

Monday Noon seminars are hosted by the Hope Center and the Department of Neurology.  Talks are organized around mini-series topics; each mini-series is organized by Hope Center faculty members to feature investigators from Washington University as well as one outside speaker. Monday Noon seminars run during the academic year, typically September through May.

All seminars are listed on the Office of Neuroscience Research (ONR) Calendar.

For inquiries, contact John Cirrito or Cindy Lawrence.

2020/2021 Schedule

Mondays, 12-1p
September – June
Zoom conference

Mini-Series Topics:

Impact of viruses on CNS function
Alternative splicing/isoforms and neurological disease
T cells and brain disease
Dynamics of CSF and Meninges
Autophagy
Down Syndrome links to Neurodegenerative Diseases – (joint Hope Center/Development Biology series)

Impact of viruses on CNS function

Organizer, David Clifford (WashU Neurology)

Mini-series recording links (WUSTL Key required)

• September 21: Robyn Klein (WashU Medicine) “Virus-mediated diseases of pathological forgetting”
• September 28: Kenneth Tyler (University of Colorado) “EV-D68 Associated acute flaccid myelitis: A new polio?”
• October 12: Steven Jacobson (NINDS/NIH) “Association of Human Herpesvirus and Chronic Progressive Neurologic Disease”
• October 19: Sean Whelan (WashU Molecular Microbiology) “Rabies virus infection of neurons”

Alternative splicing/isoforms and neurological disease

Organizers, Timothy Miller and Nathan Pomper (WashU Neurology)

Mini-series recording links (WUSTL Key required)

• November 9: Darshan Sapkota (Dougherty lab, WashU Genetics) “Alternative modes of mRNA translation and their neurological significance”
• November 16: Adrian Krainer (Cold Spring Harbor Laboratory) “From Base Pairs to Bedside: Antisense Modulation of RNA Splicing”
• November 23 “Data Blitz”
  Ya-Lin Lu (Yoo lab, WashU Developmental Biology) “Neuronal PTB-mediated alternative splicing of BAF complex subunits”
  Bryan Copits (WashU Anesthesiology) “Alternative splicing plasticity of synaptic adhesion molecules in human sensory neurons”
  Brittany Townley (Mosammaparast lab, WashU Pathology & Immunology) “Splicing defects in the pathology of trichothiodystrophy”
• November 30: Douglas Black (University of California, Los Angeles) “Mechanisms and Programs of Neuronal Gene Regulation by RNA Binding Proteins”
• December 7 “3R/4R Tau Data Blitz”
  Lucia Capano (Yoo lab, WashU Developmental Biology) “Using age-maintained, directly-reprogrammed neurons to identify human-specific tau splicing regulators”
  Miguel Minaya (Karch lab, WashU Psychiatry) “How does 4R-Tau expression affect human iPSC-Neuron maturity?”
  Lubov Ezerskiy (Miller lab, WashU Neurology)“Increase in 4R tau expression promotes astrocytic dysfunction”

T cells and brain disease

Organizer, Naresha Saligrama (WashU Neurology)

Mini-series recording links (WUSTL Key required)

• January 4: Robyn Klein (WashU Medicine) “BBB crosstalk with T cells determines their CNS entry during health and disease”
• January 11: Michal Schwartz (Weizmann Institute of Science, Israel) “The immune system holds the key to defeat Alzheimer’s disease”
• January 25: David Gutmann (WashU Neurology) “T cell regulation of brain tumor formation and growth”
• CANCELLED – February 1: Gavin Dunn (WashU Neurosurgery) “Identifying and targeting antigens in brain tumors”
• February 8: Adrian Liston (Babraham Institute, Cambridge) “Using brain Tregs to treat neuroinflammation”

Dynamics of CSF and Meninges

Organizer, Jennifer Strahle (WashU Neurosurgery)

Mini-series Zoom and recording links (WUSTL Key required)

• February 15: Jonathan Kipnis (WashU Pathology and Immunology) “Glymphatic-lymphatic system in CNS immune surveillance”
• February 22: David Limbrick, Pat McAllister (WashU Neurosurgery) “Ventricular/subventricular changes in ‘inflammatory’ hydrocephalus”
• March 1: Geir Ringstad (Oslo University Hospital) “Human CSF dynamics and craniospinal molecular clearance assessed with MRI”
• March 8: Benjamin Plog (WashU Neurosurgery) “Novel Insight into Regulation of Glymphatic Flow with Implications for Traumatic Brain Injury”
• March 15: Nathalie Jurisch-Yaksi (Norwegian University of Science and Technology) “Function of motile cilia in brain development and physiology, lesson learned from the zebrafish”

Autophagy

Organizer, David Holtzman (WashU Neurology)

Mini-series recording links (WUSTL Key required)

• March 22: Gilbert Gallardo (WashU Neurology) “Engineering Intrabodies that Target Tau for Autophagy mediated degradation”
• March 29: Abhinav Diwan (WashU Medicine) “Lysosomal pathways in Alzheimer’s disease pathogenesis: From matters of the heart to the heart of the matter”
• April 5: Conrad C. Weihl (WashU Neurology)“Autophagy and Selective Autophagy in Neurodegeneration”
• April 12: Steven Finkbeiner (University of California, San Francisco/Gladstone Institutes) “Is the autophagy/lysosomal pathway a common thread for neurodegenerative disease?”

Down Syndrome links to Neurodegenerative Diseases

Joint series with the Department of Developmental Biology

Organizer, Beau Ances (WashU Neurology)

Mini-series Zoom and recording links (WUSTL Key required)

• CANCELLED – April 26: Kelly Botteron (WashU Psychiatry)“Early Brain Development in Trisomy 21: Considerations for Neurodegeneration in the Context of a Neurodevelopmental Disorder”
• May 3: Beau Ances (WashU Neurology) “Alzheimer Disease in Adults with Down Syndrome”
• May 10: John Constantino (WashU Psychiatry) “Origins and Management of Psychiatric Complications of Down Syndrome”
• May 17: Frances Wiseman (University College London) “Understanding Alzheimer’s disease development in the context of Down syndrome; using preclinical models”
• May 24: Anita Bhattacharyya (University of Wisconsin, Madison) “Modeling neurodevelopment in Down syndrome with iPSCs”