Monday Noon Seminars

Talks organized around themes of shared biological mechanisms, neurobiology, and therapeutics Read More


Monday Noon seminars are hosted by the Hope Center and the Department of Neurology.  Talks are organized around mini-series topics; each mini-series is organized by Hope Center faculty members to feature investigators from Washington University as well as one outside speaker. Monday Noon seminars run during the academic year, typically September through May.

All seminars are listed on the Office of Neuroscience Research (ONR) Calendar.

For inquiries, contact John Cirrito or Cindy Lawrence.

2019/2020 Schedule

Mondays, 12-1p
September – June
Holden Auditorium (Farrell Learning and Teaching Center)

Mini-Series Topics:

Senescent cells in health and disease
Sex differences in disease
Molecular Neuroimaging
Phase transitions/intrinsically disordered domains
CANCELLED – Autophagy
CANCELLED – Cell fate control and function during neural development

Special Hope Center Seminars

Senescent cells in health and disease

Organizer, Jason Ulrich (WashU Neurology)

  • September 30: Sheila Stewart (WashU Cell Biology & Physiology) “Age-related stromal changes drive tumorigenesis”
  • October 7: Miranda Orr (Wake Forest University) “Targeting tau-associated cellular senescence to mitigate neurodegeneration and cognitive impairment in age-associated brain diseases”
  • October 28: Darren Baker (Mayo Clinic) “Neurodegenerative Disease Driven by Senescent Cells”
  • November 4: Shin-ichiro Imai (WashU Developmental Biology) “NAD World 3.0: The Inter-Tissue Interactions Mediated by eNAMPT and NMN in Mammalian Aging/Longevity Control”

Sex differences in disease

Organizer, Joshua Rubin (WashU Pediatrics)

  • November 25: Joshua Rubin (WashU Pediatrics) “Evolutionary and Developmental Origins of Sex Differences in Biology”
  • December 2: Trainee Talks
    • Jasmin Sponagel (Molecular Cell Biology graduate student, Rubin lab (WashU Pediatrics)) “Sex Differences in Redox State Underlie Glutamine Dependency in Male Glioblastoma”
    • Lauren Broestl (MSTP student, Rubin Lab (WashU Pediatrics)) “Astrocyte Senescence Contributes to Sex Differences in Glioblastoma Incidence and Outcome”
    • Nathan Rockwell (Molecular Cell Biology graduate student, Rubin lab (WashU Pediatrics)) “Investigating sex differences in p53 gain-of-function mutations in glioblastoma”
    • Sarah Rosen (Posdoctoral Research Scholar, Klein lab (WashU Medicine)) “Sexually Dimorphic Immune Responses to Neuroinvasive West Nile Virus”
  • December 9: Manu Goyal (WashU Radiology) “Sex differences in human metabolic brain aging”, Joseph Ippolito (WashU Radiology) “Metabolism-driven sex differences in cancer outcomes: implications for diet and obesity”
  • December 16: John Constantino (WashU Psychiatry) “Closing in on the Cause(s) of the Pronounced Sex Ratio in Autism”, Joseph Dougherty (WashU Genetics) “A model for gene-based and sex-based risk in psychiatric disease”

Molecular Neuroimaging

Organizer, Brian Gordon (WashU Radiology)

  • January 6: Ana Maria Arbelaez (WashU Pediatrics)
  • January 13: Brian Gordon (WashU Radiology) “Multimodal imaging in disease”
  • January 27: William Kreisl (Columbia University) “”What can PET imaging of translocator protein 18 kDa (TSPO) teach us about Alzheimer’s disease?””
  • February 3: Joel Perlmutter (WashU Neurology) “Neuroimaging biomarkers of parkinsonism”

Joint Hope Center/Neurology/Center for Science and Engineering of Living Systems (CSELS) Series: Phase transitions/intrinsically disordered domains

Organizers, Chris Weihl (WashU Neurology) and Alex Holehouse (WashU Biochemistry and Molecular Biophysics)

  • February 10: Carlos Castañeda (Syracuse University)“Protein droplets and ALS: Liquid-liquid phase separation of UBQLN2 is modulated by oligomerization, ALS-linked mutations, and ubiquitin binding”
  • February 24: Alex Holehouse (WashU Biochemistry and Molecular Biophysics) “The physical basis for phase separation of intrinsically disordered proteins”
  • March 2: Rohit Pappu (WashU Biomedical Engineering) “Phase separation of multivalent proteins implicated in neurodegeneration”
  • CANCELLED – March 9: James Shorter (University of Pennsylvania) “Combating deleterious phases in ALS/FTD”


Organizer, David Holtzman (WashU Neurology)

  • CANCELLED – March 23: Steven Finkbeiner (University of California, San Francisco/Gladstone Institute)
  • CANCELLED – March 30: Conrad C. Weihl (WashU Neurology)
  • CANCELLED – April 6: Gilbert Gallardo (WashU Neurology)
  • CANCELLED – April 13: Abhinav Diwan (WashU Medicine)

Cell fate control and function during neural development

Organizers, Andrew Yoo, Samantha Morris (WashU Developmental Biology)

  • CANCELLED – April 20
  • CANCELLED – May 4: Paschalis Kratsios (University of Chicago)
  • CANCELLED – May 11: Mayssa Mokalled (WashU Developmental Biology)
  • CANCELLED – May 18

Special Seminars for 2020

  • November 11: ALS Center Lecture: Jeffrey Rothstein (Johns Hopkins University) “Disassembly and Reassembly of the Nuclear Pore: Disease Initiator in ALS/Dementia”
  • CANCELLED – March 16: Special Neurology Seminar: Jae-eun Miller (Columbia University) “Shining Light on Alzheimer’s Disease”

Suggest Mini-Series Topics

Please keep in mind:

  • Anyone (PI or lab member) can suggest topics.
  • Each mini-series typically includes three speakers from Washington University, and one outside investigator.
  • You do not have to suggest particular WashU or outside speakers but, if you have suggestions, please include.

Submit mini-series topic(s)

Past Mini-Series Topics

Mini-series topics from previous seasons.

Previous mini-series