Clocks & Sleep

Organizers: Erik Herzog, Paul Taghert, and Michael Hughes Read More


The Hope Center is pleased to announce that Clocks & Sleep Club now is the Hope Center Clocks & Sleep Club.  This new affiliation reflects an expansion of the existing group, aimed to help promote ongoing research on the role of sleep and circadian rhythms in neurodegenerative disease.   The founders and organizers, Erik Herzog and Paul Taghert, will continue in their roles as the group meets monthly to discuss recent advances in the study of biological timing and sleep.

Labs working on biological rhythms include:

Erik Herzog. Molecules, cells and circuits of mammalian circadian timing.

Paul Taghert. Molecules, cells and circuits of insect circadian timing.

Dmitri Nusinow. Circadian regulation of physiology and development in plants.

David Holtzman. The role of normal and disrupted daily rhythms in amyloid beta production and Alzheimer’s Disease progression and therapies.

Michael Hughes. Daily regulation of gene expression.

Shin-Ichiro Imai. Epigenetics of circadian timing and aging.

István Kiss. Coupled oscillator behavior in biological and electrochemical systems.

Erik Musiek. The role of clock genes and circadian rhythms in neurodegeneration.

Jeanne Nerbonne. Circadian regulation of excitability and channel biology.

Paul Shaw. Genetics and benefits of sleep.

Students can sign up for and participate in Clocksclub for 1 credit at WU.

Organizers/Contact Information

For additional information about the Clocks & Sleep Club, please contact the organizers Erik Herzog, Michael Hughes or Paul Taghert, or our administrative coordinator, Jan Konrad.

2016/2017 Schedule, Clocks & Sleep Club

1st Friday of the month
BJC Institute of Health 7AB


  • September 2:
    Jerrah Holth (Holtzman Lab, WUSTL Neurology),
    “The interaction between sleep and tau pathology in the P301S tauopathy mouse model”
    Ben Palanca (WUSTL Anesthesiology),
     “Postoperative Delirium: Putative Roles of Disordered Sleep and Circadian Rhythms”
  • September 30: Benedetto Grimaldi (Istituto Italiano di Tecnologia), “Therapeutic implications of cancer-specific broken clocks”
  • SPECIAL WEDNESDAY, November 2: John Hogenesch (Cincinnati Children’s Hospital), “Time for precision medicine: from big data to novel therapeutics”
    **Note the location: BJC-IH 9AB
  • November 4: Xitong Liang (Taghert Lab, WUSTL Neuroscience), Jiajia Li (Hughes Lab, University of Missouri St. Louis)
    Xitong Liang, “Output circuits downstream of Drosophila circadian pacemakers”
    Jiajia Li, “Achilles is a circadian clock controlled gene that regulates immune function in Drosophila”
  • December 2: Scott Lewis (Hughes Lab, University of Missouri St. Louis), Sonya Bahar (University of Missouri St. Louis)
    Scott Lewis, “Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer’s disease-risk genes”
    Sonya Bahar, “Chimera States in a Hodgkin-Huxley Neural Model”
  • January 6: Matthew Tso (Herzog Lab, WUSTL Biology), “Gamma frequency entrainment attenuates amyloid load and modifies microglia”
    Dmitri Nusinow (Danforth Plant Science Center), “A hierarchical multi-oscillator network orchestrates the Arabidopsis circadian system”
  • February 3: Qianyi Yang (Chen Lab, WUSTL Anesthesiology), “Nocturnal Itch: Why do we itch at night” 
    Istvan Kiss (Saint Louis University), 
    “Resynchronization of circadian oscillators and the east-west asymmetry of jet-lag”
  • March 3: Erik Musiek (WUSTL Neurology), “REV-ERBs and Neuroinflammation”
    Markus Klose (Shaw Lab, WUSTL Neuroscience), “Sleep debt reprograms clock neuron identity”
  • April 7
  • May 5

All meetings are listed on the Neuroscience Calendar of the Office of Neuroscience Research.

Archives of previous seasons


Spring 2015

Clocks & Sleep Club Faculty

Faculty organizers: Erik Herzog, Paul Taghert, Michael Hughes

Affiliated Faculty

Erik Herzog (WUSTL Biology)
David Holtzman (WUSTL Neurology)
Michael Hughes (UMSL Biology)
Shin-Ichiro Imai (WUSTL Developmental Biology)
Yo-El Ju (WUSTL Neurology)
István Kiss (SLU Chemistry)
Brendan Lucey (WUSTL Neurology)
Erik Musiek (WUSTL Neurology)
Jeanne Nerbonne (WUSTL Internal Medicine)
Dmitri Nusinow (Donald Danforth Plant Science Center)
Paul Shaw (WUSTL Neuroscience)
Paul Taghert (WUSTL Neuroscience)
Kelvin Yamada (WUSTL Neurology)


Archive of previous Clocks & Sleep Club meetings