Anil Cashikar, PhD
Associate Professor of Psychiatry
Oxysterols in Alzheimer’s disease Read More
|Lab Phone:||(314) 273-1863|
|Lab Location:||BJC IH 9302|
|Keywords:||Oxysterol, endosome, lysosome, ApoE, cell-cell communication, inflammation|
Oxysterols in Alzheimer’s disease
Oxysterols are hydroxylated cholesterols, which influence a wide variety of cellular pathways including endolysosomal trafficking, cholesterol biosynthesis and cell surface and nuclear receptor signaling among others. These intracellular effects manifest as major regulatory steps in lipid homeostasis, inflammatory signaling, neuromodulation and cell migration. We are interested in understanding how oxysterols influence neuroinflammation, synaptic dysfunction and neurodegeneration in Alzheimer’s disease.
Last updated October 2017.