Anil Cashikar, PhD

Assistant Professor of Psychiatry

Oxysterols in Alzheimer’s disease Read More

Email: cashikar@wustl.edu
Lab Phone: (314) 273-1863
Website:
Lab Location: BJC Institute of Health, 9302
Keywords: Oxysterol, endosome, lysosome, ApoE, cell-cell communication, inflammation

Oxysterols in Alzheimer’s disease

Oxysterols are hydroxylated cholesterols, which influence a wide variety of cellular pathways including endolysosomal trafficking, cholesterol biosynthesis and cell surface and nuclear receptor signaling among others. These intracellular effects manifest as major regulatory steps in lipid homeostasis, inflammatory signaling, neuromodulation and cell migration. We are interested in understanding how oxysterols influence neuroinflammation, synaptic dysfunction and neurodegeneration in Alzheimer’s disease.

Last updated October 2017.

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