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Celeste Karch, PhD

Research Instructor in Psychiatry

Molecular mechanisms underlying tauopathies Read More

Email: karchc@psychiatry.wustl.edu
Lab Phone: (314) 747-3161
Lab Location: BJC Institute of Health 9th Floor
Website:
Keywords: neurodegeneration, neurogenetics, axon injury & repair, Alzheimer's disease, frontotemporal dementia, tau, amyloid precursor protein, induced pluripotent stem cells (iPSC), cell and molecular biology, molecular mechanisms

Molecular mechanisms underlying tauopathies

The goal of my research is to understand the molecular and cellular mechanisms underlying tauopathies. Tau dysfunction is implicated in many neurodegenerative diseases, including Alzheimer’s disease, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, and Pick’s disease. Most of these diseases are characterized by tau protein aggregation and are termed tauopathies. In these diseases, tau is affected at the molecular (splicing), protein (hyperphosphorylation, cleavage, aggregation), and cellular (secretion) levels. Thus, defining the molecular mechanisms underlying tauopathies will require unraveling the complexities of the MAPT gene that encodes the tau protein, tau protein dysfunction within the cell, and the cell-cell interactions that produce pathology in the human brain. I use traditional immortalize and primary culture models in combination with human induced pluripotent stem cell-derived neuron and astrocytes. Defining the molecular and cellular mechanisms underlying tauopathies will improve our understanding of how tau genetics influences tau biology and will inform novel avenues for therapeutic intervention.

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