Didier Hodzic, PhD
Assistant Professor of Ophthalmology & Visual Sciences
Role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and neuronal migration Read More
|Lab Phone:||(314) 362-6800|
|Lab Location:||McMillan 620|
|Keywords:||cell motility, cytoskeleton, eye development, neurons, skeletal muscle, transgenic|
Role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and neuronal migration
The Hodzic lab focuses on the role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and its relevance to nuclear migration in neuronal and muscle cells. Conditional mouse transgenic approaches are used to target the retina, cortex and skeletal muscle. The specific targeting of cortex and retina is motivated by the fact that 1) they display extensive interkinetic nuclear migration during post-mitotic cell specification, 2) they rely on glial-guided neuronal migration for their laminated pattern, 3) they are organized in laminar nuclear layers whose disorganization can be tested in vivo and 4) they allow the purification of different neuronal cell types amenable to study nuclear dynamics in vitro. The retina further allows the use of non-invasive methods to directly assess disruptive phenotypes. These experiments could significantly enhance our understanding of retina and cortex development and homeostasis and to uncover new molecular etiologies associated human diseases resulting from neuronal migration defects. Targeting of skeletal muscles will further examine the role of LINC complexes in the anchorage of synaptic nuclei beneath the post-synaptic apparatus.
Updated February 2014
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