blumer_kendall

Kendall Blumer, PhD

Professor of Cell Biology & Physiology

Signal transduction in the cardiovascular, nervous and visual systems

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Email: kblumer@wustl.edu
Lab Phone: (314) 362-1662
Website: Blumer Lab
Lab Location: McDonnell Basic Sciences Building 506
Keywords: cardiovascular disease, synaptic transmission, cancer, G proteins, molecular imaging, signal transduction, vision

Signal transduction in the cardiovascular, nervous and visual systems

Signal transduction by G protein coupled receptors (GPCRs) in the cardiovascular, nervous and visual systems is the focus of our research. GPCRs are the largest and most important class of receptors in humans because they are the targets of more than half of all therapeutic agents, as well as many drugs of abuse.

Our research focuses on RGS proteins, a large family we discovered that function as novel regulators, effectors and integrators in GPCR signaling pathways. Indeed, RGS proteins have important roles in hypertension, heart failure, anxiety, schizophrenia, vision and drug addiction. Accordingly, RGS proteins provide a promising new class of drug targets.

Currently our goals are to elucidate the mechanistic and physiological functions of RGS proteins in the cardiovascular, nervous and visual systems through biochemical, cell biological, genetic and physiologic studies of knockout and transgenic mice. We are working to: 1) determine the mechanisms whereby RGS proteins participate in hypertension and heart failure; and 2) elucidate signaling functions of the RGS7 family in the visual and nervous systems. Both projects employ a multidisciplinary approach that includes biophysics (FRET, FLIM, FRAP), biochemistry, molecular biology, real-time imaging of signaling molecules, pharmacology, and mouse physiology. New students will have the opportunity to build on current projects or to develop novel research projects.

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